罗格列酮的降压作用及对水、电解质平衡的影响
Effects of Rosiglitazone maleate on blood pressure,water-electrolyte blance in normal rats
作者：洪小平;张欣洲;马江涛;王宇罡;
Author：
收稿日期： 年卷（期）页码：2007,(01):-40-42
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：罗格列酮;血压;水电解质平衡;过氧化物酶增殖体活化γ受体;激动剂
Key words：
基金项目：
中文摘要
目的研究罗格列酮(PPARγ激动剂)对正常大鼠的降压作用与水、电解质的改变,并初步探讨两者间的联系。方法正常SD♂大鼠18只,随机分为两组,用药前测定血压、尿量、体重、24 h尿钾、尿钠,罗格列酮组ig马来酸罗格列酮40 mg.kg-1.d-1,对照组ig等量生理盐水,用药6 d后于第7天复测上述指标,并测定血钾、血钠、血氯。结果用药后罗格列酮组血压较空白对照组血压下降14.1 mmHg(P=0.003),用药后较用药前血压下降13.1 mmHg(P=0.011);较空白组血钾有所降低,但差别无统计学意义,血钠、血氯浓度比较差别亦无统计学意义。结论大剂量罗格列酮用药6 d可使正常大鼠血压下降,但对血钾、钠、氯浓度、24 h尿钾、尿钠的含量影响不大。
参考文献
[1]Kotchen TA,Zhang HY,Reddy S,et al.Effect of pioglitazoneon vascular reactivity in vivo and in vitro[J].Am J Physiol,1996,270(3 Pt 2):660-666.
[2]DieP QN,EI Mabrouk M,Cohn JS,et al.Structure,endothelialfunction,cell growth,and inflammation in blood vessels of angio-tensin II-infused rats[J].Circulation,2002,105(19):2296-2302.
[3]Niemeyer NV,Janney LM.Thiazolidinedione-induced edema[J].Pharmacotherapy,2002,22(7):924-929.
[4]Jian song,KnePPer MA,Hu X,et al.Rosiglitazone activates re-nal sodium-and water-reabsorptive pathways and lowers bloodpressure in normal rats[J].J Pharmacol Exp Ther,2004,308(2):426-433.
[5]Schnackenberg CG,Wade-Whittaker FM,Buckingham RE,etal.Insulin-induced sodiumretention is not enhanced by the thi-azolidinedione,rosiglitazone[J].J Am Soc NePhrol,2001,12(3):517A.
[6]Lihong Chen,Baichun Yang,Judi A,et al.GI262570,a pde-roxisome proliferator-activated receptorγagonist,changes elec-trolytes and water reabsorption from the distal nephron in rats[J].J Pharmacol Exp Ther,2005,312(2):718-725.
【关闭】
