混合酸酐法合成CCK-4
Synthesis of CCK-4 by Mixture anhydrides method
作者：何谷;黄维;郭丽;
Author：
收稿日期： 年卷（期）页码：2005,(06):-518-520
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：多肽;CCK-4;混合酸酐法;液相合成
Key words：
基金项目：国家自然科学基金资助项目(批准号:20472055)
中文摘要
目的液相合成Trp-Met-Asp-PheNH2四肽(CCK-4)。方法以N-保护的色氨酸、甲硫氨酸、天门冬氨酸和C-保护的苯丙氨酸为原料,采用混合酸酐法合成了CCK四肽,总收率38.5%。结果其结构经IR、1HNMR、MS确证,熔点与文献报道的一致。结论采用重复过量混合酸酐法合成了目标化合物(6),所用方法经济、有效、可靠。
参考文献
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