那格列奈和瑞格列奈对2型糖尿病患者血清MDA水平和SOD活性的影响
Comparing the effects between Nateglinide and Repaglinide on the level of serum malondialdehyde and the activity of superoxide dismutase in type 2 diabetics
作者：殷霞;李建薇;喻红玲;田浩明;
Author：
收稿日期： 年卷（期）页码：2005,(06):-500-502
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：那格列奈;瑞格列奈;2型糖尿病;氧化应激;血清丙二醛;超氧化物歧化酶
Key words：
基金项目：
中文摘要
目的观察那格列奈和瑞格列奈治疗2型糖尿病患者空腹和餐后2h的血清丙二醛(malondialdehyde,MDA)水平以及超氧化物歧化酶(super oxide dismutase,SOD)活性的变化。方法采用随机双盲双模拟阳性对照试验,将46例血糖控制不佳的2型糖尿病患者随机分为两组,分别接受那格列奈(A组)和瑞格列奈(B组)治疗。84d后,比较两种药物对空腹及餐后2h血糖、MDA、SOD、抗氧化比值(AOR=SOD/MDA)以及糖化血红蛋白的影响。结果A组空腹及餐后2h血糖、糖化血红蛋白下降幅度均大于B组,但两者间差异仅空腹血糖具有统计学意义(P=0.033)。两种药物均可显著降低餐后MDA水平(P
参考文献
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