三七三醇皂苷增进大鼠脑缺血耐受的作用及对GFAP和bFGF表达的影响
Promotion effects of PTS on ischemic tolerance and expression of GFAP and bFGF in rats
作者：周俊英;刘小利;罗祖明;
Author：
收稿日期： 年卷（期）页码：2005,(06):-489-492
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：三七三醇皂苷;缺血耐受;胶质纤维酸性蛋白;碱性成纤维细胞生长因子
Key words：
基金项目：
中文摘要
目的观察三七三醇皂苷(PTS)对预缺血诱导的脑缺血耐受作用及胶质纤维酸性蛋白(GFAP)、碱性成纤维细胞生长因子(bFGF)表达的影响。方法采用改进的二次线栓法制备SD大鼠缺血耐受模型,并随机分为大脑中动脉缺血(MCAO)组、预缺血组(IP+MCAO)和PTS组(IP+PTS+MCAO),分别给予10min的假手术、预缺血或预缺血加PTS,3d后使MCAO2h,再灌注22h后处死,比较各组神经功能评分、梗死体积、病理形态学变化及GFAP和bFGF的表达。结果PTS组神经功能缺损减轻、梗死体积缩小和病理形态学改变均较预缺血组更为明显,GFAP、bFGF表达均高于其余两组(P
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