文拉法辛对抑郁症患者睡眠的影响
Effects of Venlafaxine on the sleep of depressed patients
作者：邓先华;孙学礼;张波;舒放;唐娴;刘协和;
Author：
收稿日期： 年卷（期）页码：2007,(03):-351-353
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：抑郁症;文拉法辛;多导睡眠描记术;睡眠
Key words：
基金项目：国家十五攻关课题资助项目(项目编号:2004DA7210A21)
中文摘要
目的探讨文拉法辛对抑郁症患者多导睡眠图及主观睡眠质量的影响。方法对20名抑郁症患者及30名正常对照者进行多导睡眠图检测,并应用匹兹堡睡眠质量指数(PSQI)和汉密尔顿抑郁量表(HAMD)睡眠障碍因子分评定抑郁症患者的主观睡眠质量。比较治疗前后多导睡眠图指标和主观睡眠质量的变化。结果与对照组比较,病例组显示多导睡眠图指标异常。病例组经过文拉法辛治疗后与治疗前比较,多导睡眠图显示觉醒次数和觉睡比增加、睡眠效率降低、睡眠阶段S1百分比增加、快眼动(REM)睡眠时间及百分比减少、REM睡眠潜伏期延长、REM活动度及强度降低,但PSQI和HAMD睡眠障碍因子分均明显降低。结论文拉法辛能抑制抑郁症患者的REM睡眠,并加重睡眠维持障碍,导致浅睡眠增加,但能够明显改善患者的主观睡眠质量。
参考文献
[1]Luthringer R,Toussaint M,Schaltenbrand N,et al.Adouble-blind,placebo-controlled evaluation of the effects of orally ad-ministered venlafaxine on sleep in inpatients with major depres-sion[J].Psychopharmacology Bulletin,1996,32(4):637-646.
[2]刘贤臣,唐茂芹.匹慈堡睡眠质量指数的信度和效度研究[J].中华精神科杂志,1996,29:103-107.
[3]Rechtschaffen A,Kales A.A manual of standardized terminolo-gy,techniques,and scoring system for sleep stages in humansubjects[M].3rd.Los Angels:Brain Information Service/Brainresearch Institute of University of Califonia,1973.1-2.
[4]Berger M,van Calker D,Riemann D.Sleep and manipulationsof the sleep-wake rhythmin depression[J].Acta PsychiatricaScandinavica,Supplementum,2003,(418):83-91.
[5]Seifritz E.Contribution of sleep physiology to depressive patho-physiology[J].Neurop sychopharmacology,2001,25(5 Sup-pl):S85-S88.
[6]Kienke AS,Rosenbaum J F.Efficacy of venlafaxine in the treat-ment of severe depression[J].Depression&Anxiety.2000,12Suppl 1:50-54.
[7]Trivedi MH,Rush AJ,Armitage R,et al.Effects of fluoxetineon the polysomnogram in outpatients with major depression[J].Neuropsychopharmacology,1999,20(5):447-459.
[8]Giedke H,Klingberg S,Schwarzler F,et al.Direct comparisonof total sleep deprivation and late partial sleep deprivation in thetreatment of major depression[J].J Affecti Disorders,2003,76(1-3):85-93.
【关闭】
