非洛地平-美托洛尔复方贴剂经不同动物皮肤的药物渗透性
Comparative study on percutaneous permeability of Felodipine-Metoprolol transdermal patch through different excised animal skins in vitro
作者：王文刚;恽榴红;王睿;付桂英;刘泽源;
Author：
收稿日期： 年卷（期）页码：2008,(02):-155-157
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：非洛地平;美托洛尔;透皮贴剂;经皮渗透性
Key words：
基金项目：
中文摘要
目的制备非洛地平-美托洛尔复方透皮贴剂并研究经不同动物皮肤的体外药物渗透特性。方法采用改良的Franz透皮扩散装置,分别以离体小鼠、大鼠和兔皮肤为渗透屏障,生理盐水-乙醇(60:40)为接受液,用HPLC同时测定经皮渗透液中两药物的浓度,并计算渗透动力学参数。结果贴剂中,非洛地平和美托洛尔48 h内均以零级动力学经不同动物皮肤转运,并具一定同步性,动物皮肤对药物渗透性依次为:小鼠>大鼠>兔。结论非洛地平-美托洛尔复方透皮贴剂缓释长效特征明显,药物体外经皮渗透性稳定,各指标均可满足治疗血药浓度的要求。
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