载药胶束在大鼠血液和组织中的分布
Distribution of 9-nitro-20(S)-camptothecin loaded micelles in the blood and organs of rats
作者：高界铭;邹文;明静;顾忠伟;张兴栋;
Author：
收稿日期： 年卷（期）页码：2008,(02):-138-140
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：胶束;组织分布;9-硝基喜树碱
Key words：
基金项目：国家重点基础研究规划项目(973)(2005CB623903)
中文摘要
目的评价负载9-硝基喜树碱(9-NC)共聚物胶束在大鼠血液和组织中的分布情况。方法大鼠尾静脉注射1.5mg.kg-1载药胶束,在各时间点测定血液和组织样品中的药物浓度,检测波长370 nm。结果与原料药相比,载药胶束能降低其在网状内皮组织的药物分布浓度,并有效延长血液循环时间;可穿越血脑屏障,实现药物在大脑组织中的分布。结论共聚物胶束能延长9-NC在血液中的循环时间和改善在大鼠体内的组织分布。
参考文献
[1]Sands H,Mishra A,Stoeckler JD,et al.Preclinical activity ofan iv formulation of rubitican in IDD-PTM against human solidtumor xenografts[J].Anti Drugs,2002,13(9):965-975.
[2]Lavasanifar A,Samuel J,Kwon GS.Micelles self-assembledfrom poly(ethylene oxide)-block-poly(N-hexyl stearateL-aspartamide)by a solvent evaporation method:effect on thesolubilization and haemolytic activity of amphotericin B[J].JContr Rel,2001,77:155-160.
[3]Li Ke,Zhong Dafang.Determination of 9-nitrocamptothecin inrat plasma and tissues by high performance liquid chromatography[J].Acta Pharm Sinica,2003,38:124-128.
[4]Ahmed AE,Jacob S,Giovanella BC,et al.Comparative disposi-tion of the antineoplastic agent 9-nitrocamptothecin and the in-active isomer 12-nitrocamptothecin in CASE-bearing nudemice:effect of route of administration on tissue distribution[J].Cancer Chemother Pharm,1997,41(1):29-36.
[5]Lobenberg R,Araujo L,Von Briesen H,et al.Body distributionof azidothymidine bound to hexy-cyanoacrylate nanoparticles af-ter iv injection to rats[J].J Contr Rel,1998,50:21-30.
[6]Koshkina NV,Gilbert BE,Waldrep JC,et al.Distribution ofcamptothecin after delivery as a liposome aerosol or following in-tramuscular injection in mice[J].Cancer Chemother Pharm,1999,44(3):187-192.
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