微波辅助合成东莨菪素
Synthesis of scopoletin with assisted microwave irradiation
作者:方专;何光力;何菱;
Author:
收稿日期: 年卷(期)页码:2007,(03):-302-303
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:微波;东莨菪素
Key words:
基金项目:
中文摘要
目的设计东莨菪素合成的新工艺。方法利用微波合成东莨菪素。结果与结论所用方法可缩短反应时间,提高反应的选择性和收率,可用于工业化生产。
参考文献
[1]杨柯,林启云,赵一,等.东莨菪素对家兔体温的影响[J].广西中医药,2005,28(1):62.
[2]宋蔚,刘锁兰,李秀青,等.HPLC测定4种丁公藤类生药中东莨菪素及东莨菪苷的含量[J].中国中药杂志,2004,29(2):185-186.
[3]吴立宏,朱恩圆,张紫佳,等.广西产丁公藤原植物的调查及商品丁公藤主流品种的鉴定[J].中草药,2005,36(9):1398-1400.
[4]Handbook of Fine Chemicals and Laboratory Equipment[M].USA:Aldrich,2000-2001.1624.
[5]Zhao Xiaohong,Chen Dihua,Si Jianyong,et al.Studies on thephenolic acid constituents from Chinese midecine"Shengma",rhizome ofCimicifuga foetida[J].Yaoxue Xuebao,2002,37(7):535-538.
[6]Abdel-kader,Maged S.New ester and furocoumarins from theroots ofPiturathos tortuous[J].J Brazilian Chem Society,2003,14(1):48-51.
[7]Son Yeon-kyoung,Lee Minghong,Han Yongnan.A new antip-sychotic effective nealignan from Firmiana simplex[J].Archivesof Pharmacal Research,2005,28(1):34-38.
[8]孙文基,杨旭民.天然药物成分提取分离与制备[M].北京:中国医药科技出版社,1999.367-369.
[9]Jan Demyttenaere,Stijn Vervisch,Silvia Debenedetti,et al.Synthesis of virgatol and virgatenol,two naturally occurring cou-marins from pterocaulon virgatum(L.)DC,and 7-(2,3-ep-oxy-3-methylbutoxy)-6-methoxycoumarin,isolated fromconyza obscura DC[J].Synthesis,2004,11:1844-1848.
[10]Angela M,Bernard M,Rossella Ghiani,et al.Dealkylation ofactivated alkyl aryl ethers using lithium chloride in dimethyl-formamide[J].Synthesis,1989,4:287-289.
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