葡萄籽原花青素对大鼠脑缺血再灌注后NF-κB、IκB和iNOS的影响
Effects of grape seed proanthocyanidins extract on the expression of NF-κB,IκB and iNOS in rat after focal cerebral ischemia-reperfusion
作者：陈荣志;陆景红;任明山;李光武;余锋;许文华;
Author：
收稿日期： 年卷（期）页码：2007,(03):-266-268
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：葡萄籽原花青素;脑缺血再灌注;核因子-κB;诱导型一氧化氮合酶
Key words：
基金项目：
中文摘要
目的探讨葡萄籽原花青素(GSPE)对大鼠脑缺血再灌注后NF-κB,IκB和iNOS的影响。方法采用线栓法建立大鼠右侧大脑中动脉缺血再灌注模型。将72只SD大鼠随机均分成假手术组、缺血再灌注组和GSPE组,于缺血2 h再灌注6、24、48 h时断头取脑,选取视交叉前后各1 mm的脑组织,采用免疫组化法检测核因子-κB(NF-κB)、抑制蛋白-κB(IκB)、诱导型一氧化氮合酶(iNOS)的表达,观察GSPE对其的影响。结果缺血再灌注组NF-κB的表达较GSPE组显著增加(P
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