基于β-苯基萘型化合物的合成及其抗肿瘤活性的初步筛选
Synthesis of compounds based on the β-phenylnapthalene type and screening of its anticancer biological activities
作者：蒋龙天;何菱;曾红;
Author：
收稿日期： 年卷（期）页码：2007,(03):-242-244
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：过渡金属催化合成;N-N亚胺叶立德;1,3-偶极环加成;β-苯基萘型平面化合物;吲唑[2.3-a]喹啉;BEL-7402
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基金项目：
中文摘要
目的合成新的β-苯基萘型平面产物,并初步筛选其抗肿瘤活性。方法过渡金属催化合成N-N键亚胺叶立德,并进行1,3-偶极环加成形成共平面产物。结果合成了吲唑[2.3-a]喹啉,收率中等。结论筛选显示,产物10b具有抑制人肝癌BEL-7402瘤株的活性。
参考文献
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