龟板、黄芪、丹参、党参上调K562细胞~Gγ-珠蛋白mRNA的表达
Accumulation of ~Gγ-globin mRNA in K562 cells induced by Tortois plastron,Radix Astragali,Radix and Radix Codonopsitis
作者：郭志梅;李海军;钱新华;
Author：
收稿日期： 年卷（期）页码：2008,(03):-260-262
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：龟板、黄芪、丹参、党参;K562细胞;Gγ-mRNA
Key words：
基金项目：
中文摘要
目的研究龟板、黄芪、丹参、党参在体外对K562细胞Gγ-珠蛋白mRNA表达的上调作用。方法以K562细胞为体外模型,应用荧光定量RT-PCR技术研究药物诱导后Gγ-珠蛋白基因mRNA表达水平的变化。结果龟板、黄芪、丹参、党参作用K562细胞5 d后,Gγ-珠蛋白mRNA的表达增加(最高达3.7倍)。与丁酸钠组比较,黄芪组诱导K562细胞Gγ-珠蛋白基因mRNA的表达可持续3~5 d,而丁酸钠组仅1 d。结论龟板、黄芪、丹参、党参有望成为一种有效的γ蛋白基因诱导剂。
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