二氢嘧啶脱氢酶抑制剂吉美拉西的合成
Synthesis of dihydropyrimidine dehydrogenase inhibitor Gimeracil
作者:刘宇;戚苏明;王浦海;丁逸梅;
Author:
收稿日期: 年卷(期)页码:2008,(03):-252-254
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:二氢嘧啶脱氢酶;抑制剂;吉美拉西;合成
Key words:
基金项目:
中文摘要
目的合成吉美拉西并改进其合成工艺。方法以丙二腈为起始原料,经缩合、环合、氯化、水解等5步反应制得吉美拉西。结果所得产物经元素分析、紫外光谱、红外光谱、核磁共振谱及质谱等确证了结构。结论改进后的合成路线可行。
参考文献
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