GC-MS测定氙在不同浓度脂肪乳中的分配系数
Determination partition coefficients of Xenon in lipid emulsion of different concentration by GC-MS
作者：曹伟;李章万;刘进;张文胜;
Author：
收稿日期： 年卷（期）页码：2007,(04):-423-425
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：氙气;脂肪乳;气相色谱质谱联用;分配系数
Key words：
基金项目：
中文摘要
目的建立测定氙气脂肪乳/气分配系数的方法。方法氙气浓度测定采用毛细管气相色谱法和注射器-注射器二次平衡法测定氙气在脂肪乳中的分配系数。结果氙气在3.125%～0.012%线性关系良好(r=0.998),最低检测限为2×10-6。氙气在脂肪乳中的分配系数与脂肪乳的浓度成正比,即氙气在10%、20%和30%脂肪乳中分配系数之比约为1:2:3。结论脂肪乳剂不能作为氙气静脉制剂的载体,应寻找溶解度更大的载药体系。
参考文献
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