舒心饮干预大鼠动脉粥样硬化中相关炎症因子的激活实验
An experimental study on effects of Shuxin Yin on prevention of atherosclerosis
作者：汤诺;何燕;沈琳;林钟香;
Author：
收稿日期： 年卷（期）页码：2007,(04):-398-401
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：舒心饮;动脉粥样硬化;炎症;致炎因子
Key words：
基金项目：上海市高等学校科技发展基金资助项目(03CK12)
中文摘要
目的通过研究舒心饮对动脉粥样硬化形成过程中相关致炎因子的影响和量效关系,阐明舒心饮干预和延缓动脉粥样硬化形成的可能机制。方法72只♂SD大鼠被随机均分为空白组、模型组、舒降之组、舒心饮低、中、高剂量组。观察血脂和AngⅡ、光镜下胸主动脉的病理变化、胸主动脉内膜致炎因子MMP-9及TIMP-1蛋白的表达。结果舒心饮能显著降低血清总胆固醇,升高HDL/TC的比值,降低血管紧张素Ⅱ;显著降低动脉内膜厚度、泡沫细胞阳性内膜面积及其占内膜总面积的百分比;显著降低MMP-9的蛋白表达和MMP-9/TIMP-1的比值,显著增加TIMP-1的蛋白表达。中剂量舒心饮可能是抗动脉粥样硬化治疗的最佳剂量。结论舒心饮能影响动脉粥样硬化形成过程中炎症的启动和致炎因子的激活,延缓其进程,稳定其斑块,预防和治疗动脉粥样硬化性疾病。
参考文献
[1]何燕,林钟香,顾仁樾,等.舒心饮治疗30例冠心病的临床观察[J].上海中医药杂志,2001,35(11):11-13.
[2]Libby P.Inflammation in atherosclerosis[J].Nature,2002,420:868-874.
[3]Dollery CM,McEwan JR,Henney AM.Matrix metalloproteinasesand cardiovascular diseas[J].Circ Res,1995,77:863-868.
[4]Galis ZS,Khatri JJ.Matrix metalloproteinases in vascular remod-eling and atherogenesis:the good,the bad,and the ugly[J].Circ Res,2002,90:251-262.
[5]Sternlicht MD,Werb Z.How matrix metalloproteinases regulatecell behavior[J].Annu Rev Cell Dev Biol,2001,17:463-516.
[6]Schoenhagen P,Ziada KM,Kapadia SR,et al.Extent anddirection of arterial remodeling in stable versus unstable coronarysyndromes:an intravascular ultrasound study[J].Circulation,2000,101:598-603.
[7]Takeo Higashikata,MasakazuYamagishi.Altered expression bal-ance of matrix metalloproteinases and their inhibitors in humancarotidplaquedisruption:Results of quantitative tissue analysisusing real-time RT-PCR method[J].Atherosclerosis,2006,185:165-172.
[8]Morishige K,Shimokawa H,Matsumoto Y,et al.Overexpressionof matrix metalloproteinase-9 promotes intravascular thrombusformation in porcine coronary arteriesin vivo[J].Cardiovasc Res,2003,57:572-585.
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