TRAIL联合顺铂和IFN-α对人肝癌细胞凋亡的影响
Apoptosis of hepatoma cells induced by a combination of TRAIL,Cisplatin and IFN-α
作者：胥瑜;闫娟;李旭锋;陈守春;
Author：
收稿日期： 年卷（期）页码：2007,(04):-390-392
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：TRAIL;IFN-α;顺铂;肝癌细胞;联合;细胞凋亡
Key words：
基金项目：
中文摘要
目的探讨肿瘤坏死因子相关凋亡诱导配体(TRAIL)联合顺铂和IFN-α应用对人肝癌细胞生长抑制和诱导凋亡的作用。方法用SRB染色法测定TRAIL、顺铂、IFN-α单独或联合应用对人肝癌细胞SMMC7721的体外增殖抑制作用,并检测各组细胞凋亡率。结果TRAIL、顺铂、IFN-α三者联合作用于SMMC7721细胞后,顺铂与IFN-α联用的体外生存率从70.91%±3.43%降至34.81%±3.10%,细胞凋亡率从12.47%±0.91%升至45.50%±6.25%。结论TRAIL、顺铂、IFN-α三者联用能显著提高肝癌细胞SMMC7721生长抑制和诱导凋亡作用。
参考文献
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