Bosentan预防大鼠低氧性肺动脉高压形成的作用
Bosentan preventing hypoxic pulmonary arterial hypertension
作者：李生花;靳国恩;
Author：
收稿日期： 年卷（期）页码：2008,(04):-429-430
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：Bosentan;预防;低氧性肺动脉高压
Key words：
基金项目：
中文摘要
目的研究Bosentan预防低氧诱导的肺动脉高压发生的药效作用,探讨内皮素-1(ET-1)在慢性高原病发病中的作用。方法30只Wistar大鼠随机均分为常氧对照组、低氧对照组和Bosentan组,将低氧对照组和Bosentan组放入模拟海拔为5.5 km的低氧、低压环境中。常氧对照组和低氧对照组ig 0.9%生理盐水,Bosentan组ig 100 mg.ml-1Bosentan水剂,每天2次。饲养15 d后,测量大鼠平均肺动脉高压(PAP)、左右心室比重[RV/(LV+S)]比值。结果Bosentan组大鼠血红蛋白(Hb)、红细胞压积(Hct),ET-1与低氧对照组相比无差异,而PAP、RV/(LV+S)均显著低于低氧对照组(P
参考文献
[1]Hoeper MM,Faulenbach C,Golpon H,et al.Combination thera-py with bosentan and sildenafil in idiopathic pulmonary arterialhypertension[J].Eur Respir J,2004,24:1007-1010.
[2]Lewis J,Rubin MD,David B,et al.Bosentan therapy for pulmo-nary arterial hypertension[J].N Engl J Med,2002,346(16):1258-1265.
[3]Ge RL,Kubo K,Kobayashi T,et al.Blunted hypoxic vasocon-strictive response in the rodent Ochotona curzoniae(pika)athigh altitude[J].Am J Physiol,1998,274(Heart Cire Physio l43):H1792.
[4]Stephen HL,Richard NC.Endothelin antagonism in pulmonaryarterial hypertension[J].Semin Respir Crit Care Med,2005,26(4):402-408.
[5]Galie N,Manes A,Branzi A.The endothelin system in pulmona-ry arterial hypertension[J].Cardiovasc Res,2004,61:227-237.
[6]Nobutake S,Subrina J,Sohel Z,et al.EPA effect on NOS geneexpression and NO level in endothelin-1-induced hypertro-phied cardiomyocytes[J].Exper Bio Med,2006,231:913-918.
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