难溶性药物兰索拉唑口服结肠定位片的制备及体外释药性
Preparation and release in vitro of colon-targeted tablet of indissolvable drug Lansoprazole
作者：林珂;赖会明;涂莉;吴熠;何勤;
Author：
收稿日期： 年卷（期）页码：2008,(04):-394-396
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：结肠靶向;兰索拉唑;β-甘露聚糖酶;瓜尔胶
Key words：
基金项目：四川省杰出青年基金(批准号:05ZQ026-009)
中文摘要
目的制备难溶性药物兰索拉唑结肠靶向(Lansoprazole colon-targeted,LPZ-CT)片并考察处方及释放条件对片剂释药行为的影响。方法湿法制粒压片得兰索拉唑速释片芯,采用喷雾包衣与压制包衣结合的方法制备pH与酶双重敏感的LPZ-CT片。结果速释片芯体外溶出度达70%以上。当pH层包衣增重为7%,压制包衣层含20%瓜尔胶时,LPZ-CT片在模拟胃、小肠环境的介质中不释药,在模拟结肠环境介质(pH7.4,0.2 g.L-1β-甘露聚糖酶)中,累积释放度达80%以上。结论LPZ-CT片体外实验满足药物溶出和精确定位结肠的要求。
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