盐酸四环素缓释微球的制备
Preparation of sustained release microspheres of Tetracycline-HCl
作者：李莉;黄永灿;常丽;李驯虎;张珏;唐莉;邓力;
Author：
收稿日期： 年卷（期）页码：2008,(04):-391-393
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：PLGA;微球;缓释;正交设计
Key words：
基金项目：国家高技术研究发展计划(863)资助项目(2001AA216011);;
北京科学技术委员会科技计划重大资助项目(H060920050730)
中文摘要
目的制备盐酸四环素聚乳酸-聚羟基乙酸共聚物(PLGA)微球并优化其工艺。方法采用复乳-溶剂蒸发法制备盐酸四环素PLGA微球,以微球包封率为检测指标,通过单因素试验和正交试验优选最佳制备工艺。结果在优化条件下制备的微球形态规则,粒径为16.72±0.33μm,载药量为0.52%±0.01%,包封率为78.56%±1.05%,微球的体外释药规律符合Higuichi方程(r=0.9986)。结论该制备工艺合理,为制备盐酸四环素PLGA微球提供了理论基础。
参考文献
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