乳化异氟醚与芬太尼麻醉作用的相互影响
Inferaction between Fentanyl with Emulsified isoflurane
作者：杨经文;陈燕;高安量;张文胜;刘进;
Author：
收稿日期： 年卷（期）页码：2007,(05):-527-529
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：乳化异氟醚;芬太尼;麻醉作用;等辐射分析
Key words：
基金项目：国家自然科学基金项目(批准号:30271259)
中文摘要
目的探讨芬太尼与乳化异氟醚在大鼠给予夹尾刺激时,其麻醉作用的相互影响。方法75只健康♂SD大鼠随机均分为芬太尼组、芬太尼+乳化异氟醚组、乳化异氟醚组,以夹尾是否有四肢或躯体发生逃避反射作为终点指标,采用序贯法分别测定各组药物的ED50,用Dixon-Mood法计算药物的ED50,用等辐射方法和algebraic分析法分析药物的相互影响。结果3组间大鼠体重无显著性差异;通过等辐射分析和algebraic分析显示芬太尼和乳化异氟醚是协同作用(P
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