乳化异氟醚和脂肪乳对大鼠心脏缺血再灌注损伤的影响
Cadioprotective effects of emulsified isoflurane and intralipid on ischemia-reperfusion injury in isolated rat heart
作者：刘陕岭;刘进;
Author：
收稿日期： 年卷（期）页码：2007,(05):-525-527
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：乳化异氟醚;脂肪乳;心脏保存;缺血-再灌注损伤
Key words：
基金项目：
中文摘要
目的研究乳化异氟醚和脂肪乳加入心脏保存液,对心脏复灌后的缺血再灌注损伤的影响。方法采用大鼠Langen-dorff心脏灌流及低温保存缺血再灌注损伤模型,测定乳化异氟醚和脂肪乳对心脏机械功能、冠脉流出液中磷酸肌酸激酶(CK)和乳酸脱氢酶(LDH)和心梗面积的影响。结果乳化异氟醚和脂肪乳均可显著增强左室发展压(LVDP),显著减少冠脉流出液中CK和LDH的含量,减少心梗面积。结论乳化异氟醚和脂肪乳加入心脏保存液能改善心脏机械功能,减少CK、LDH的释放,并缩小心梗面积。
参考文献
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