载胰岛素微球的包衣工艺
作者：石海涛;龚涛;
Author：
收稿日期： 年卷（期）页码：2007,(06):-712-713
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：羟基磷灰石;胰岛素;微球;包衣;优特奇
Key words：
基金项目：
中文摘要
目的探索载有胰岛素的多孔羟基磷灰石微球包裹Eudragit(-L100的方法。方法采用乳化-溶剂挥发法对载药多孔羟基磷灰石微球进行包衣,考察溶剂用量、抗黏剂用量和转速等因素对包衣效果的影响。结果采用20 mg硬脂酸铝、5ml混合溶剂、1.1×103r.min-1磁力搅拌可得达要求的包衣微球。结论选择恰当的工艺参数可包衣10~80μm的微球。
参考文献
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