原花青素二聚体的药理研究进展
作者:丁伟斌;王爱琴;梁统;周克元;
Author:
收稿日期: 年卷(期)页码:2008,(05):-582-585
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:原花青素二聚体;药理作用;研究进展
Key words:
基金项目:广东省社会发展领域科技计划(KZ0698);;
广东省教育厅重点学科建设基金(GX0307)
中文摘要
原花青素二聚体是一种具有抗氧化、清除自由基、防治心血管疾病、抗癌、抗炎等多种药理功能的药用有效成分,具有广泛的开发价值。
参考文献
[1]国植,徐莉.原花青素:具有广阔发展前景的植物药[J].国外医药植物药,1996:11(5)196-204.
[2]Gabetta B,Fuzzati N,Griffini A,et al.Characterization of proan-thocyanidins from grape seeds[J].Fitotera Pia,2000,71(2):162-175.
[3]Toshiaki A,Ikunori K,Danji F.Antioxidative properties of procya-nidins B-1 and B-3 from azuki beans in aqueous systems[J].Agri Biol Chem,1988,52(11):2717-2722.
[4]Arpentine G,Fernandez Y,Bourzeix M,et al.Liaion-grouperelation between the structure of a series of procyanidins and theirradical superoxide scavenger capacity[J].process Group polyphe-nols 1992,16(1):237-240.
[5]Silva PA,Laranjinha JA,Freitas VA.Antioxidant protection of lowdensity lipoprotein by procyanidins:structure/activity relation-ships[J].Biochem pharmacol,2003,66(6):947-954.
[6]Sugiyama H,Akzome Y,Shoji T,et al.Oligomeric procyanidinsin apple polyphenol are main active components for inhibition ofpancreatic lipase and triglyceride absorption[J].J Agric FoodChem,2007,55(11):4604-4609.
[7]Chen DM,Cai X,Kwik-Uribe CL,et al.Inhibitory effects of pro-cyanidin B(2)dimer on lipid-laden macrophage formation[J].Cardiovasc pharmacol,2006,48(2):54-70.
[8]Mao TK,Van de Water J,Keen CL,et al.Cocoa Flavonols andprocyanidins promote Transforming Growth Factor-β1 Homeosta-sis in peripheral Blood Mononuclear Cells[J].Exp Biol Med(Maywood),2003,228(1):93-99.
[9]Aruoma OI,Sun B,Fujii H,et al.Lowmolecular proanthocyani-din dietary biofactor Oligonol:Its modulation of oxidative stress,bioefficacy,neuroprotection,food application and chemopreven-tion potentials[J].Biofactors,2006,27(1-4):245-265.
[10]Seeger H,Deuringer FU,Wallwiener D,et a1.Breast cancer riskduring HRT:influence of estradio1 metabolites on breast canceran dendothelial cell proliferation[J].Maturitas,2004,49(3):235-240.
[11]Kijima I,Phung S,Hur G,et al.Grape seed extract is an aro-matase inhibitor and a suppressor of aromatase expression[J].Cancer Res,2006,66(11):5960-5967.
[12]Agarwal C,Veluri R,Kaur M,et al.Fractionation of high molecu-lar weight tannins in grape seed extract and identification of pro-cyanidin B2-3,3’-di-O-gallate as a major active constitu-ent causing growth inhibition and apoptotic death of DU145 hu-man prostate carcinoma cells[J].Carcinogenesis,2007,28(7):1478-1484.
[13]Mao TK,Van WJ,Keen CL,et al.Effect of cocoa flavanols andtheir related oligomers on the secretion of interleukin-5 in pe-ripheral blood mononuclear cells[J].J Med Food,2002,5(1):17-22.
[14]Takano F,Takata T,Yoshihara A,et al.Aqueous extract of pea-nut skin and its main constituent procyanidin A1 suppress serumIgE and IgG1 levels in mice-immunized with ovalbumin[J].Bi-ol pharm Bull,2007,30(5):922-927.
[15]Mackenzie GG,Carrasquedo F,Delfino JM,et al.Epicatechin,catechin,and dimeric procyanidins inhibit PMA-induced NF-kappaB activation at multiple steps in Jurkat Tcells[J].FASEBJ,2004,18(1):167-169.
[16]Zhang WY,Liu HQ,Xie KQ,et al.procyanidin dimer B2[epicat-echin-(4beta-8)-epicatechin]suppresses the expression ofcyclooxygenase-2 in endotoxin-treated monocytic cell[J].Bio-chem Biophys Res Commun,2006,345(1):508-515.
[17]Hou DX,Masuzaki S,Hashimoto F,et al.Green tea proanthocyani-dins inhibit cyclooxygenase-2 expression in LPS-activatedmouse macrophages:molecular mechanisms and structure-activityrelationship[J].Arch Biochem Biophys,2007,460(1):67-74.
[18]Jo JY,Gonzalez ME,Lila MA.Effects of grape cell culture ex-tracts on human topoisomerase II catalytic activity and character-ization of active fractions[J].J Agric Food Chem,2005,53(7):2489-2498.
[19]Sakano K,Mizutani M,Murate M,et al.procyanidin B2 has anti-and pro-oxidant effects on metal-mediated DNA damage[J].Free Radic Biol Med,2005,39(8):1041-1049.
[20]Versteraren SV,Hammerstone JF,Keen CL,et al.Antioxidant andmembrane effects of procyanidin dimers and trimers isolated frompeanut and cocoa[J].J Agric Food Chem,2005,53(12):5041-5048.
[21]Kamimura A,Takahashi T,Morohashi M,et al.procyanidin oli-gomers counteract TGF-beta1-and TGF-beta2-induced ap-optosis in hair epithelial cells:an insight into their mechanisms[J].Skin Pharmacol Physiol,2006,19(5):259-265.
[22]Kamimura A,Takahashi T.procyanidin B-3,isolated from bar-ley and identified as a hair-growth stimulant,has the potentialto counteract inhibitory regulation by TGF-beta1[J].Exp Der-matol,2002,11(6):532-541.
[23]Kamimura A,Takahashi T.procyanidin B-2,extracted from ap-ples,promotes hair growth:a laboratory study[J].Br J Dermatol,2002,146(1):41-51.
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