槲皮素的药理学研究进展
作者:舒毅;谭陶;张思宇;吴红崑;
Author:
收稿日期: 年卷(期)页码:2008,23(06):-689-691
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:槲皮素;抗肿瘤;抗氧化;心血管保护;抗病毒
Key words:
基金项目:
中文摘要
综述天然黄酮类化合物槲皮素在抗肿瘤、抗氧化、抗血栓、抗糖尿病及保护心血管和止泻等方面的药理作用。
参考文献
[1]Hollman PC,Kata MB.Dietary flavonoids:intake,health effects and bioavailability[J].Food Chem Toxicol,1999,37(9-10):937-942.
[2]Morrow DM,Fitzsimmons PE,Chopra M,et al.Dietary supple-mentation with the anti-tumour promoter quercetin:its effects on matrix metalloproteinase gene regulation[J].Mutation Re-search,2001,480-481:269-276.
[3]Akira Murakami.Mutitargeted cancer prevention by quercetin[J].Cancer Lett,2008,03:046-056.
[4]钟璐,陈芳源.槲皮素对K562细胞生长及血管内皮生长因子分泌的影响[J].白血病.淋巴瘤,2006,15(3):161-163.
[5]刘荣耀,王家东.槲皮素对人喉鳞状细胞癌细胞系Hep-2的作用[J].临床耳鼻咽喉头颈外科杂志,2008,22(40):169-171.
[6]翟莺莺,周蕾.槲皮素抗肿瘤作用的研究[J].现代临床医学生物工程学杂志,2005,11(1):18-20.
[7]Pedrielli,Skibsted LH.Antioxidant synergy and regeneration effect of quercetin,(-)-epicatechin,and(+)-catechin on alpha-tocopherol in homogeneous solutions of peroxidating meth-yl linoleate[J].J Agric Food Chem,2002,50:7138-7144.
[8]Choi EJ,Chee KM,Lee BH.Anti-and proxidant effects of chronic quercetin administration in rats[J].Eur J Pharmacol,2003,482:281-285.
[9]Rao,CV,Bijaya KM.Effect of quercetin,flavonoids andα-to-copherol,an antioxidant vitamin on experimental reflux oesoph-agitis in rats[J].Eur J Pharmacol,2008,10:1016-1021.
[10]贾小燕,闫素清,柴保臣,等.槲皮素-钼配合物对超氧阴离子和羟自由基的清除作用[J].华西药学杂志,2008,23(1):042-044.
[11]Ziegenhagen MW,Schrum S,Zissel G,et al.Increased expres-sion of proinflammatory chemokines in bronchoalveolar lavage cells of patients with progressing idiopathic pulmonary fibrosis and sarcoidosis[J].J Investig Med,1998,46:223-231.
[12]Agnes WB,Lonneke CW,Els LRS.In vitroand exvivo anti-in-flammatory activity of quercetin in healthy volunteers[J].Nutri-tion,2008,24:703-710.
[13]Nair MP,Mahajan S,Reynolds JL,et al.The flavonoid quercetin inhibits proinflammatory cytokine(tumor necrosis factor alpha)gene expression in normal peripheral blood mononuclear cells via modulation of the NF-kappabeta system[J].Clin Vaccine Im-munol,2006,13:319-328.
[14]刘佳佳,羊建,邬于川,等.中性粒细胞自发性凋亡及槲皮素对其影响的研究[J].医学研究杂志,2007,36(1):66.
[15]肖东,顾振纶.槲皮素对血小板激活时胞浆游离钙的影响[J].苏州医学院学报,1995,15(1):40-42.
[16]Plotnikov MB,Aliev OI,Maslov MJ,et al.Correction of haemo-rheological disturbances in myocardial infarction by diquertin and ascorbic acid[J].Phytother Res,2003,17(1):86-88.
[17]Hubbard GP,Wolffram S,Lovegrove JA,et al.Ingestion of quer-cetin inhibits platelet aggregation and essential components of the collagen-stimulated platelet activation pathway in humans[J].J Thromb Haemost,2004,2(12):2138-2145.
[18]Chu SC,Hsieh YS,Lin JY.Inhibitory effects of flavonoids on Ma-loney murine leukemia virus reverse transcriptases activity[J].J Natural Products,1992,55:179-183.
[19]毛晓明.槲皮素对糖尿病大鼠肾脏的保护作用[J].江苏医药,1999,25(9):670-671.
[20]傅静奕,田浩明,梁荩忠.槲皮素对糖尿病大鼠肾脏的保护作用及机制[J].中华内分泌代谢杂志,2000,16(1):47-48.
[21]曾云先,刘尚勤.槲皮素对糖尿病大鼠降糖作用的观察[J].华夏医学,1999,1(1):34-35.
[22]贾淑明,刘铜华.常用中药及其活性成分抗糖尿病的作用机制[J].国际中医中药杂志,2007,29(4):254-256.
[23]陈辉.槲皮素的心血管保护作用[J].国际心血管病杂志,2007,34:57-59.
[24]林蓉,刘俊田,李旭,等.槲皮素对血管内皮细胞损伤的保护作用.中国循环杂志,2006,15(5):304-305.
[25]Wu S,Ko YS,Teng MS,et al.Adriamycin-induced cardiomyo-cyte and endothelia cell apoptosis:in vitro and in vivo studies[J].Mol Cell Cardiol,2002,34(12):1595-1607.
[26]裴天仙,徐长庆,于靖,等.槲皮素抗阿霉素诱导的培养心肌细胞的凋亡[J].中国药理学通报,2008,24(4):534-538.
[27]Lutterodt GD.Inhibition of gastrointestinal release of acetylcho-line by quercetin as possiblemode of action of psidium guojava leaf in the treatment of acute diarrboeal diseas[J].J Ethnophar-macol,1989,25(3):23-247.
[28]张文举,陈宝田,王彩云,等.槲皮素止泻机制研究[J].第一军医大学学报,2003,25(3):282-285.
[29]Wu SN,Chiang HT,Shen AY,et al.Differential effects of querce-tin,a natural polyphenolic flavonoid,on L-type calcium current in pituitary tumor(GH3)cells and neuronal NG108-15cells[J].J Cell Physiol,2003,23(10):1029-1031.
[30]于利人,张东昌,王瑞珉,等.槲皮素诱导K562细胞凋亡机制探讨[J].中国肿瘤临床,2005,32(9):505-507.
[31]吴国志,毕方方,杨晓苏,等.槲皮素对脑缺血再灌后FADD蛋白表达的影响[J].神经疾病与精神卫生,2007,7(1):1-6.
[32]Ahn.The anti-obesity effect of quercetin is mediated by the AMPK and MAPK sinaaling pathways[J].Biochem Biophys Res Commun,2008,6:77-81.
[33]Gloria GV,Manuel JE,Silvia M.The effect of flavonoids on trans-duction mechanisms in lipopolysaccharide-treated human gingi-val fibroblasts[J].International Immunopharmacology,2007,7:1199-1210.
[34]陈德才,魏松全.槲皮素对体外培养的SD大鼠破骨细胞增殖及凋亡的影响[J].华西药学杂志,2002,17(1):16-18.
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