跨血脑屏障药物载运中转铁蛋白受体抗体作用的研究进展
作者:陈剑鸿,王碧江,刘松青,王章阳
Author:
收稿日期: 年卷(期)页码:2003,(01):-33-35
期刊名称:华西药学杂志
Journal Name:WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字:转铁蛋白受体;血脑屏障;药物载运
Key words:
基金项目:
中文摘要
综述了从转铁蛋白受体抗体与药物之间不同的连接方式并讨论了以转铁蛋白受体抗体为基础的中枢神经系统药物载运措施的研究进展
参考文献
1 MoosT ,MorganEH .Transferrinandtransferrinreceptorfunctioninbrainbarriersystems[J].CellMolNeurobiol,2000,20(1):77
2 LeeHJ,EngelhardtB ,LesleyJ.Targetingratanti-mousetransferrinre ceptormonoclonalantibodiesthroughblood-brainbarrierinmouse[J].JPharmacolExpTher,2000,292(3):1048
3 ShiN ,Pardridge.WMNoninvasivegenetargetingtothebrain[J].ProcNatl.AcadSciUSA ,2000,97(13):7567
4 KuriharaA ,PardridgeWM .Imagingbraintumorsbytargetingpeptidera diopharmaceuticalsthroughtheblood-brainbarrier[J].CancerRes,1999,59(24):6159
5 WuD ,PardridgeWM .Neuroprotectionwithnoninvasiveneurotrophinde liverytothebrain[J].ProcNatlAcadSciUSA ,1999,96(1):254
6 DeguchiY ,KuriharaA ,PardridgeWM Retentionofbiologicactivityofhumanepidermalgrowthfactorfollowingconjugationtoablood-brainbarrierdrugdeliveryvectorviaanextendedpoly(ethyleneglycol)linker[J].BioconjugChem.1999,10(1):32
7 LeeHJ ,BoadoRJ ,BraaschDA ,etal.ImaginggeneexpressioninthebraininvivoinatransgenicmousemodelofHuntington’sdiseasewithanantisenseradiopharmaceuticalanddrug-targetingtechnology[J].JNuclMed,2002,43(7):948
8 SongBW ,VintersHV ,WuD ,etal.Enhancedneuroprotectiveeffectsofbasicfibroblastgrowthfactorinregionalbrainischemiaafterconjugationtoablood-brainbarrierdeliveryvector[J].JPharmacolExpTher,2002,301(2):605
9 PenichetML ,KangYS ,PardridgeWM ,etal.Anantibody-avidinfu sionproteinspecificforthetransferrinreceptorservesasadeliveryvehicleforeffectivebraintargeting:initialapplicationsinanti-HIVantisensedrugdeliverytothebrain[J].JImmunol,1999,163(8):4421
10KuriharaA ,DeguchiY ,PardridgeWM .Epidermalgrowthfactorradio pharmaceuticals:111Inchelation,conjugationtoablood-brainbarrierdeliveryvectorviaabiotin-polyethylenelnker,pharmacokinetics,andinvivoimagingofexperimentalbraintumors[J].BioconjugChem,1999,10(3):502
11KuriharaA ,DeguchiY ,PardridgeWM .Geneticallyengineeredbraindrugdeliveryvectors:cloning,expressionandinvivoapplicationofananti-transferrinreceptorsinglechainantibody-streptavidinfusiongeneandprotein[J].ProteinEng,1999,12(9):787
12McGrathJP ,CaoX ,SchutzA ,etal.Bifunctionalfusionbetweennervegrowthfactorandatransferrinreceptorantibody[J].JNeurosciRes,1997,47(2):123
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