多烯磷脂酰胆碱脂质纳米粒冻干粉针的制备工艺
Preparation of lyophilized polyene-phosphatidylcholine lipid nanoparticles
作者：曾丹;赵栋;韩静;龚涛;
Author：
收稿日期： 年卷（期）页码：2009,24(01):-19-21
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：多烯磷脂酰胆碱;脂质纳米粒;制备工艺
Key words：
基金项目：
中文摘要
目的筛选多烯磷脂酰胆碱脂质纳米粒(PPC-LN)的处方和工艺条件。方法采用熔融乳化-高压匀质法制备PPC-LN,以单因素试验考察影响制备PPC-LN的处方和工艺因素,通过正交设计对处方和工艺条件进行优化,同时,对冻干脂质纳米粒的理化性质进行考察。结果所得纳米粒为圆整的类球形实体粒子,平均粒径为135±12nm,包封率为97.4%±0.9%,PDI为0.169±0.004。结论熔融乳化-高压匀质法可用于PPC-LN的制备,制成的冻干品包封率高,粒径分布均匀,成型良好。
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