胰岛素粉雾剂与注射剂治疗2型糖尿病患者IAA的研究
Antibody response to insulin dry powder inhalation or subcutaneous regular insulin injection in the patients with poor-controlled type 2 diabetes mellitus
作者：王椿;张祥迅;余婷婷;袁南兵;喻红玲;龙洋;田浩明;冉兴无;
Author：
收稿日期： 年卷（期）页码：2008,23(06):-643-645
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：胰岛素;吸入;2型糖尿病;胰岛素自身抗体
Key words：
基金项目：
中文摘要
目的评价胰岛素粉雾剂治疗2型糖尿病患者胰岛素自身抗体(IAA)的发生情况。方法保持原口服降糖药不变,试验组加吸入型胰岛素治疗,对照组加sc胰岛素治疗,疗程均为13周。比较治疗前后两组糖化血红蛋白(HbA1c)、空腹及餐后2h血糖和IAA,并在试验结束后6个月随访复查IAA。结果两组的HbA1c分别下降了0.73%、1.19%,两组均未发现呼吸道的不良反应;试验组较对照组IAA阳性率更高(28.5%比18.2%),但停止使用吸入胰岛素后6个月,所有患者抗体滴度明显下降,1例抗体转阴,2/3的患者抗体滴度降至接近正常。试验组抗体滴度与吸入剂量和使用疗程相关,但与疗效无关。结论胰岛素粉雾剂与sc胰岛素的降糖疗效相当,但吸入胰岛素后产生胰岛素抗体的几率更高,所产生的抗体与吸入的剂量、疗程相关。因此,长期使用吸入胰岛素的糖尿病患者应监测是否有胰岛素自身抗体的产生。
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