异穿心莲内酯3,19-双酯类衍生物的合成与表征
Synthesis and characterization of 3,19-dicarbonyl-o-isoandrographolide derivatives
作者：杨爽风;顾军;李灵芝;
Author：
收稿日期： 年卷（期）页码：2009,24(02):-110-112
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：异穿心莲内酯;合成;酯化反应;3,19-双脂类衍生物
Key words：
基金项目：
中文摘要
目的设计并合成异穿心莲内酯衍生物。方法以DCC为缩合剂,DMAP为催化剂,合成异穿心莲内酯3,19-双酯衍生物。结果合成并表征了9个异穿心莲内酯3,19-双酯衍生物及2个异穿心莲内酯19-单酯衍生物。异穿心莲内酯与羧酸及缩合剂DCC的摩尔比为1.0:2.5:2.5,于室温下反应4~6 h。结论所合成化合物结构均经1HNMR、MS确证。
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