HPLC法及毛细管电泳法在手性药物拆分中的应用
作者：黄河,戴晓莉,倪江洪
Author：
收稿日期： 年卷（期）页码：2003,(04):-277-279
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：HPLC法;毛细管电泳法;手性;拆分
Key words：
基金项目：
中文摘要
建立高专属性、高灵敏度、高分离度的对映体拆分和测定方法 ,对提高药物的活性、减小副作用、深入研究药物的作用机理等具有重要的理论和实际意义。
参考文献
1 EtoS ,NodaH ,NodaA .Chiralseparationofbarbituratesandhydan toinsbyreversed phaseHPLCusinga25or50mmshortODScartridgecolumnviabeta cyclodextrininclusioncomplexes[J].JChromatogr,1992,579(2):253
2 谢剑炜,杨造萍,阮金秀.手性药物对映体的环糊精手性流动相、手性固定相HPLC拆分[J].药学学报,1998,33(2):143
3 KarlssomA .Streospecificdeterminationandinvivomonodeiodinationofthyroxineenantiomorsineuthyroidman[J].Metebolism,1985,34:266
4 范柏,袁雯玮,杉井,等.手性HPLC拆分氧氟沙星对映体[J].中国药学杂志,1998,33(11):693
5 BerthodA ,JinHL ,BeesleyTE ,etal.Cyclodextrinchiralstationaryphaseforliquidchromatographicseparationsofdrugstereoisomers[J].JPharmBiomedAnal,1990,8(2):123
6 PirkleWH ,WelchCJ,HgunMH .Achiralmodelforthechromato graphicresolutionofN -arcylatedl aryl l aminoalkanes[J].JOrgChem,1983,48:5022
7 OkamotoY ,KawashimaM ,HotadaK .Chromatographicresolution+controlledchiralrecognitionofcellulosetriphenylcarbamatederivativessupportedonsilicagel[J].JChromatogr,1992,574(1):85
8 钟大放,顾景凯,王亚芹.手性药物对映体的HPLC分离与生物样品分析[J].沈阳药科大学学报,1997,14(3):175
9 陈冰,蔡卫民,万伟.人血浆中普罗帕酮的对映体浓度的立体选择性HPLC测定法[J].中国药学杂志,1998,33(9):546
10 WainerIW ,DoyleTD ,FryFSJr,etal.Chiralrecognitionmodelfortheresolutionofephedrineandrelatedalpha,beta aminoalcoholsasenantiomericoxazolidinederivatives[J].JChromatogr,1986,355(1):149
11 SallustoBC ,AbasA ,HayballPJ,etal.EnantionspecificHPLCanal ysisof2 phenylpropionicacid.Ketoprofenandfenoprofen[J].JChro matogr,1986,374(2):329
12 蔡卫民,裴斐,陈冰.立体选择性HPLC法测定血浆中华法令对映体浓度[J].中国药学杂志,1996,31(6):330
13 蔡卫民,景华,陈冰,等.心脏瓣膜病人口服华法令后的对映体药动学[J].中国药学杂志,1997,32(3):152
14 PharrDY ,FuZS ,SmithTK .Solubilizationofcyclodextrinforanalyti calapplications[J].AnalChem,1989,61(3):275
15 TerabeS ,MiyashitaY ,IshihamaY ,etal.Cyclodextrin modifiedmi cellarelectrokineticchromatography[J].JChromatogr,1993,636:47
16 KuhnR ,StiecklinF ,ErniF .Chiralseparationbyhost gestcomplexa tionwithcyclodextrinandcrownetherincapillaryzoneelectrophoresis[J].Chromatographia,1992,34(1/2):33
17 BuschS ,JohanCK ,PoppeH .Chiralseparationbycomplextionwithproteinsincapillaryzoneelectrophoresis[J].JChromatogr,1993,635:119
18 WienbergerR .PraciticalCapillaryElectrophoresis[M ].NewYork,1993
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