大剂量维生素B_2联合托吡酯预防偏头痛发作的半随机对照研究
Controlled clinical trial of high-dose Vitamin B_2 combined with Topiramate in the prophylaxis of migraine
作者：杨强;罗军;邓华;曾薇;周沐科;
Author：
收稿日期： 年卷（期）页码：2009,24(03):-259-262
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：维生素B2;托吡酯;偏头痛;半随机对照研究
Key words：
基金项目：
中文摘要
目的评价大剂量维生素B2联合托吡酯预防偏头痛发作的效果及安全性。方法采用半随机对照研究,凡符合入选标准的患者按就诊号的奇、偶数随机分别进入试验组和对照组。试验组每次给予25 mg托吡酯(bid)、400 mg维生素B2(qd),连续服用60 d;对照组每次给予25 mg托吡酯(bid),连续服用60 d。观察治疗前后头痛发作频率、程度、持续时间的变化,评价预防效果。结果两组治疗后头痛发作频率、程度、持续时间均较治疗前有所改善(P
参考文献
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