甲基丙烯酰紫草素的抗肿瘤作用及其机制的研究
Antitumor effect and mechanism of methyl-acrylshikonin
作者：邵振俊;伍怡颖;郑小卫;万莉红;熊文碧;周黎明;
Author：
收稿日期： 年卷（期）页码：2009,24(03):-241-243
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：甲基丙烯酰紫草素;移植瘤;NF-κB p50;细胞凋亡
Key words：
基金项目：
中文摘要
目的研究甲基丙烯酰紫草素(MA)在体内外的抗肿瘤作用,并探讨其作用机制。方法用MTT法和生长曲线法研究不同浓度的MA对SGC-7901细胞的生长抑制作用;应用S180荷瘤小鼠模型进行其体内抗瘤实验;免疫组化法检测凋亡相关蛋白NF-κB p50的表达。结果MA对SGC-7901细胞具有抑制作用,且呈明显的量效和时效关系,其IC50=14.12±1.83mg.L-1;0.375、0.750、1.500 mg.kg-1的MA对小鼠移植性肉瘤S180的抑制率分别为25.00%、41.20%、61.11%,呈剂量依赖性;随着MA浓度的增大,NF-κB p50蛋白的表达下调。结论MA具有较好的体内外抗肿瘤作用,可能与诱导细胞凋亡和抑制NF-κB p50的活性有关。
参考文献
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