胸腺五肽多囊脂质体的制备及体外释放的考察
Preparation and drug release in vitro of Thymopentin multivesicular liposomes
作者：左佼;赵越;张志荣;李艳贞;石三军;龚涛;
Author：
收稿日期： 年卷（期）页码：2009,24(03):-229-231
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：胸腺五肽;多囊脂质体;包封率;体外释放
Key words：
基金项目：
中文摘要
目的制备胸腺五肽多囊脂质体,并考察其包封率和体外释放情况。方法采用复乳法制备胸腺五肽多囊脂质体,并用单因素、正交实验对处方进行优化。结果制备的胸腺五肽多囊脂质体的外观圆整均匀,形态良好,包封率为80.15%±3%。体外释放的零级动力学方程为:Y=0.536X+20.431(r2=0.9814),132 h的累积释放率为92.01%。结论复乳法制备的胸腺五肽多囊脂质体的工艺可行,包封率较高,有明显的缓释特征。
参考文献
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