姜黄素对脑缺血大鼠SOD活性及Akt磷酸化水平的影响
Effect of curcumin on SOD activity and Akt phosphorylation level in cerebral ischemic rat
作者：董凌琳;郭富强;解宇环;
Author：
收稿日期： 年卷（期）页码：2009,24(04):-351-353
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：姜黄素;脑缺血;超氧化物歧化酶;Akt磷酸化
Key words：
基金项目：
中文摘要
目的探讨姜黄素对脑缺血模型大鼠SOD酶活性及Akt磷酸化水平的影响。方法48只SD大鼠随机均分为假手术组、手术模型组、姜黄素低、高剂量组。采用Zea Longa线栓法制作模型,检测各组大鼠的SOD活性和Akt磷酸化水平。结果与假手术组比,模型组和姜黄素低、高剂量组SOD活性下降;与模型组比较,姜黄素低、高剂量组SOD活性升高(P0.05);与假手术组比较,模型组的Akt磷酸化水平显著下降(P
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