重组腺病毒mCD40L联合5-Fu治疗小鼠腹腔肿瘤的研究
Combination of recombinant adenovirus encoding mCD40L gene therapy with 5-Fu improves therapeutic efficacy of murine carcinoma
作者：吴红兵;文艳君;王虎;郑广宁;魏于全;
Author：
收稿日期： 年卷（期）页码：2009,24(04):-334-336
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：CD40配体;重组腺病毒载体;5-氟尿嘧啶;肿瘤生物化疗
Key words：
基金项目：国家自然科学基金资助项目(批准号:10675089)
中文摘要
目的探讨重组腺病毒鼠CD40配体基因(Ad-mCD40L)对小鼠CT26腹腔肿瘤的治疗作用。方法建立小鼠CT26腹腔肿瘤动物模型,检测腺病毒介导的鼠CD40配体基因联合5-Fu对肿瘤生长的抑制作用。结果腹腔内灌注Ad-mCD40L+5-Fu,可明显抑制CT26肿瘤结节的生长。Ad-mCD40L能激发小鼠特异的免疫反应,增强诱导肿瘤细胞凋亡的作用,抑制肿瘤细胞的增殖。结论Ad-mCD40L联合5-Fu可产生更强的抗肿瘤效应,为结肠癌的生物-化疗提供了新的思路。
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