3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2H-3-苯并氮杂-2-酮合成工艺的改进
Synthesis of 3-(3-chloropropyl)-1,3,4,5-tetrahydro-7,8-dimethoxyl-2H-3-benzazepin-2-one
作者：海莉;钱珊;吴勇;刘光明;
Author：
收稿日期： 年卷（期）页码：2009,24(05):-471-472
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：伊伐布雷定;心绞痛;中间体;合成
Key words：
基金项目：国家自然科学基金资助项目(批准号:29972013)
中文摘要
目的改进3-(3-氯丙基)-1,3,4,5-四氢-7,8-二甲氧基-2H-3-苯并氮杂-2-酮的合成工艺。方法以3,4-二甲氧基苯乙酸为原料,先后经氯代、酰化、环和、取代和氢化等反应合成目标化合物。结果与结论改进后的方法操作简单,易于纯化,试剂价廉易得,适合于工业化生产,总产率由44%提高到48%。
参考文献
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