骨化三醇A环合成子合成的研究进展
作者：党乐;方维臻;冯海婷;陆群;
Author：
收稿日期： 年卷（期）页码：2009,24(06):-675-677
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：骨化三醇;会聚合成法;A环合成子
Key words：
基金项目：
中文摘要
概述近年来骨化三醇合成的研究进展,介绍会聚合成法中A环部分的3种合成方法,即A环膦氧化物、A环烯丙基炔化物和非环状A环。
参考文献
[1]Moeenrezakhanlou Al,Shephard L,Lam L,et al.Myeloid cell differentiation in response to calcitriol for expression CD116and CD14is regulated by myeloid ziznc finger-1protein downstream of phosphatidy linostitol3-kinase[J].J Leukocyte Biology,2008,84(2):517-528.
[2]Krishnan A,Moreno J,Nonn L,et al.Calcitriol as a chemopreven-tive and therapentic agent in prostate cancer:role of anti-inflam-matory activity[J].J Bone Mineral Res,2007,22(2):74-80.
[3]阮以旻,吕鉴泉,胡文祥,等.天然甾体合成1α,25-二羟基维生素D3的研究进展[J].湖北化工,2001,2:5-7.
[4]Zhu GD,Okamura WH.Synthesis of Vitamin D(Calciferol)[J].Chem Rev,1995,95:1877-1952.
[5]Masakazu K,Georges PJH,Fumie S.An efficient enantioselec-tive synthes is of1α,25-Dihydroxyvitamin D3A-ring synthon[J].Tetrahedron Lett,2000,41:2389-2390.
[6]Ichiro H,Takayuki D,Takashi T.Parallel synthesis of a Vitamin D3library in the solid-phase[J].J Am Chem Soc,2001,123(6):3716-3722.
[7]Hiyamizu H,Ooi H,InomotoY,et al.A concise enantioselective synthesis of a key A-ring synthon for1-hydroxyvitamin D3compounds[J].Org Lett,2001,3:473-480.
[8]William HM,Katelyn B,Connell.Furan approach to the synthe-sis of the A-ring of Vitamin D analogues[J].Tetrahedron Lett,2003,44:1161–1163.
[9]Kniilker HJ,Achim E,Petra S.Enantioselective synthesis of calcit-riol A-ring fragments[J].Teranhedron,1997,53(1):91-108.
[10]Sara V,Maurits V.A chemoenzymatic synthesis of A-ring key-intermed iates for1α,25-dihydroxyvitamin D3and analogues[J].Tetrahedron Lett,1995,36(49):9023-9026.
[11]Robert MM,Joonggon K,Harry BH.A general synthetic route to A ring hydroxylated Vitamin D analogs from pentoses[J].Tetra-hedron Lett,1995,36(1):51-54.
[12]Katsuhiro K,Shojiro M,Toshie F,et al.A novel and practical route to A-ring synthon for1α,25-diHydroxyvitamin D3ana-logs:Aynthesis of A-ring diastereomers of1α,25-dihydroxy vitamin D3and2-methyl-1,25-dihydroxyvitamin D3[J].Bioorg Med nal Chem Lett,1998,8:15l-l56.
[13]Achmatowicz B,Przezdziecka A,Wicha J.Synthesis of the en-antiomer of1α,25-dihydrox y Vitamin D3(Calcitriol)and a di-astereomer of1α,25-dihydroxy Vitamin D3differing from natu-ral product in configuration at all but one asymm etric carbon at-oms[J].Polish J Chem,2005,79:1-16.
[14]Teruhiko I,Shushiro I,Masataka I,et al.Synthesis of A-ring frag-ments of lα,25-dihydroxyvitamin D3and taxane diterpenoids:Ef-fective construction of conjugated formylcyclohexene frameworks from isoxazolines[J].Tetrahedron,1998,54:5869-5882.
[15]Barbara A,Pawel J,Jerzy W.Enantioselective syntheses of a1α-hydroxyvitamin D ring A precursor from3-(triphenylsilyl)gly-cidol and from malic acid[J].Tetrahedron Lett,1996,37(31):5589-5592.
【关闭】
