多柔比星壳聚糖纳米粒的制备及其体外评价
Preparation and in vitro release of Chitosan nanoparticles containing Doxorubicin
作者：于艳芳;陆兔林;毛春芹;
Author：
收稿日期： 年卷（期）页码：2009,24(06):-612-614
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：多柔比星;壳聚糖;三聚磷酸钠;纳米粒
Key words：
基金项目：
中文摘要
目的制备多柔比星壳聚糖纳米粒,并研究其包封情况和控释能力。方法采用离子交联法制备多柔比星壳聚糖纳米粒,激光粒度仪测定粒径的分布,HPLC法测定纳米粒的包封率,透析法测定多柔比星壳聚糖纳米粒的体外释放情况。结果壳聚糖的浓度增加,纳米粒的粒径增加、包封多柔比星的效率也增加;壳聚糖溶液的pH增加,纳米粒的粒径降低而包封多柔比星的效率增加;壳聚糖分子量增加对多柔比星的包封效率影响较小,但粒径增加,多柔比星突释减小,释放速率降低。结论多柔比星可以通过离子交联法制备壳聚糖纳米粒,其粒径、包封率可控,具有缓释效果。
参考文献
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