氢化泼尼松的肝毒性机理研究
LIVER TOXICITY OF PREDNISOLONE IN MICE
作者：吴东方,彭仁琇,汪晖,孔锐
Author：
收稿日期： 年卷（期）页码：1998,(01):-7-9
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：氢化泼尼松;脂质过氧化;膜流动性;谷胱甘肽S-转移酶
Key words：
基金项目：
中文摘要
氢化泼尼松（Ｐｒｅｄ）１０、２０ｍｇ／ｋｇ可显著增加肝脏ＭＤＡ含量，降低肝微粒体及线粒体膜荧光强度（Ｆ）、荧光偏振度（Ｐ）及平均微粘度（η），同时肝匀浆及微粒体ＧＳＴ酶活性亦降低，结果表明Ｐｒｅｄ可增加肝脏膜脂质过氧化作用及膜流动性，降低ＧＳＴ酶催化的研结合功能。
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