谷氨酸转运体摄取抑制剂对大鼠脑缺血神经元死亡的影响
EFFECT OF GLUTAMATE UPTAKE INHIBITOR ON CEREBRAL ISCHEMIC NEURONAL DEATH IN RATS
作者：晏义平,马小红,孙凤艳
Author：
收稿日期： 年卷（期）页码：1998,(04):-235-237
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：脑缺血;谷氨酸转运体;L-反式吡咯烷-2，4－二羧酸;神经毒
Key words：
基金项目：国家自然科学基金
中文摘要
实验观察了谷氨酸转运体摄制剂L-反式吡咯烷-2，4-二羧酸（L－trans－PDC）对脑缺血大鼠神经元死亡的影响。脑室注射L－trans－PDC5μg使大鼠脑梗塞体积显著增大；侧脑室注射L－trans－PDC1μg，2μg或5μg对大鼠脑缺血后脑血流量无显著影响，表明抑制谷氨酸转运体摄取将加重脑缺血致神经元死亡，提示谷氨酸转运体在限制脑缺血时谷氨酸神经毒中起重要作用。
参考文献
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