氟氯苯菊酸的合成工艺优化
Optimization of the synthetic process of fluoropermethrin
作者：阳治军,余洋洋,任成,张加强,陆群
Author：
收稿日期： 年卷（期）页码：2020,35(03):-237-239
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：氟氯苯菊酸;合成工艺;优化;对氯苯乙酮;固体三光气;正交实验;单因素试验;工业化生产
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基金项目：
中文摘要
目的优化氟氯苯菊酸的合成工艺。方法改用廉价的对氯苯乙酮及稳定的固体三光气为原料,合成氟氯苯菊酸;同时采用正交试验、单因素试验对反应条件进行优化。结果经4步反应,成功制得了氟氯苯菊酸,提高了产物的收率。结论所用方法可满足工业化生产的要求。
参考文献
[1] Reinhard Lantzsch,Dieter Arlt,Manfred Jautelat.Preparation of 3-vinyl-substituted 2,2-dimethylcyclopropane-1-carboxylic acids and esters and intermediates therefor[P].US 355,578.1991-2-12.
[2] Rainer Fuchs,Wilhelm Stendel.Optically active isomers of trans-3-(2-chloro-2-(4-chloro-phenyl)-vinyl)-2,2-dimethyl-cyclopropane-1-carboxylic acid alpha-cyano-4-fluoro-3-phenoxy-benzyl ester and their use as ectoparasiticides[P].US 840,355.1988-9-20.
[3] Rainer Fuchs,Fritz Maurer,Uwe Priesnitz,et al.Preparation of substituted (cyclo)alkanecarboxylic acid alpha -cyano-3-phenoxy-benzyl esters[P].US 173,545.1982-9-21.
[4] Rainer Fuchs,Ingeborg Hammann,Bernhard Homeyer,et al.Combating pests with novel phenoxypyridylmethyl esters[P].US 355,044.1985-1-1.
[5] Zhong WH,Jiang LB,Guo BM,et al.Efficient synthesis of a new type of baylishillman adducts and their stereoselective bromination[J].Synth Commun,2010,40(16):2441-2456.
[6] 陈小明.氟氯苯菊酯的合成简述[J].广东化工,2012,39(15):57-58.
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