3-硝基-2H-色烯衍生物的合成及抗菌活性研究
Synthesis and evaluation of 3-nitro-2H-chromene derivatives as new antibacterials
作者：肖国强;殷霞;胡志鹏;鄢明;
Author：
收稿日期： 年卷（期）页码：2012,27(03):-235-237
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：3-硝基-2H-色烯衍生物;合成;抗菌活性;定量构效关系
Key words：
基金项目：国家自然科学基金资助项目(批准号:21172270);;
珠海市科技计划资助项目(PC20081006)
中文摘要
目的设计并合成一系列3-硝基-2H-色烯衍生物,研究其抗菌活性与构效关系。方法以水杨醛和2-硝基乙醇为原料合成目标化合物,采用肉汤稀释法测定抗菌活性。结果目标化合物结构均经过1HNMR和HRMS确证,3-硝基-2H-色烯衍生物对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌具有很好的抑制活性(MIC=4μg·mL-1)。结论 3-硝基-2H-色烯衍生物具有进一步深入研究的价值。
英文摘要
[1]Hunter PA,Dawson S,French GL,et al.Antimicrobial-resistantpathogens in animals and man:Prescribing,practices and policies[J].J Antimicrob Chemother,2010,65(1):3-17.
[2]Caron WP,Mousa SA.Prevention strategies for antimicrobialresistance:A systematic review of the literature[J].Infect DrugResist,2010,3:25-33.
[3]Johnson AJ,Kumar RA,Rasheed SA,et al.Antipyretic,analge-sic,anti-inflammatory and antioxidant activities of two majorchromenes from Melicopelunu-ankenda[J].J Ethnopharmacol,2010,130:267-271.
[4]Iwata N,Kitanaka S.Tetracyclic chromane derivatives fromrhododendron anthopogonoides[J].J Nat Prod,2010,73:1203-1206.
[5]Conti C,Desideri N.New 4H-chromen-4-one and 2H-chromene derivatives as anti-picornavirus capsid-binders[J].Bioorg Med Chem,2010,18:6480-6488.
[6]Jain N,Xu J,Kanojia RM,et al.Identification and structure activ-ity relationships of chromene-derived selective estrogen receptormodulators for treatment of postmenopausal symptoms[J].J MedChem,2009,52:7544-7569.
[7]Batista Jr.JM,Lopes AA,Ambrósio DL,et al.Natural chromenesand chromene derivatives as potential antitrypanosomal agents[J].Biol Pharm Bull,2008,31:538-540.
[8]Wayne PA.Performance standards for antimicrobial susceptibilitytesting:19th informational supplement[S].Clini Lab Stan Insti-tute,2009,29:M100-S19.
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