可用于制备非天然氨基酸的新型甘氨酸Ni(Ⅱ)螯合物的合成
Synthesis of novel Ni(Ⅱ)-complexes of glycine for preparation of unnatural amino acid
作者：陈正军;何谷;郭丽;
Author：
收稿日期： 年卷（期）页码：2014,29(02):-109-112
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：苏氨酸;丝氨酸;非天然氨基酸;甘氨酸Ni(II)螯合物;合成
Key words：
基金项目：国家自然科学基金资助项目(批准号:81001357)
中文摘要
目的为了研究非天然氨基酸的合成,推广其在现代制药工业中的应用,设计并合成了环苏氨酸(丝氨酸)洐生化的甘氨酸Ni(Ⅱ)螯合物。方法以苏氨酸(丝氨酸)为原料,通过与甲醛成环,(Boc)2O保护氨基,再与2-氨基-二苯甲酮成酰胺,脱Boc上的苄基后,最后与Gly和Ni(Ⅱ)在碱性环境下形成平面正方形螯合物。结果和结论目标化合物Ⅱa~d及Ⅲ经1HNMR、MS确证结构。
英文摘要
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