静脉注射用胰岛素三嵌段共聚物纳米粒的制备
Preparation of insulin-loaded triblock copolymeric nanoparticle drug delivery system for intravenous injection
作者：徐雄良;段友容;符垚;胡海燕;张志荣;
Author：
收稿日期： 年卷（期）页码：2006,(04):-321-324
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：三嵌段共聚物;纳米粒;胰岛素;包封率
Key words：
基金项目：国家科技部“十五”攻关项目(批准号:004AA273142)
中文摘要
目的研究静脉注射用胰岛素三嵌段共聚物纳米粒(Ins-PELGE-NPs)的制备工艺,并考察其影响因素。方法通过复乳/溶剂扩散法制备Ins-PELGE-NPs,并考察其形态、粒径分布、包封率、zeta电位等。结果载药量为4.48%~4.67%的Ins-PELGE-NPs在透射电镜下均呈球形或近球形,分布均匀,平均粒径为140 nm,平均包封率为94%~98%,平均zeta电位为-21.7±4.3 mV。结论所用制备工艺简单、包封率高,可用于系列注射用三嵌段共聚物纳米粒的制备。
英文摘要
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