共聚物胶束对硝基喜树碱内酯环稳定性的影响
Effect of copolymer micelles on lactone stability of 9-nitro-20(S)-camptothecin
作者：高界铭;顾忠伟;张兴栋;
Author：
收稿日期： 年卷（期）页码：2008,(01):-1-3
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：胶束;9-硝基喜树碱;稳定性;高效液相色谱
Key words：
基金项目：国家重点基础研究规划项目(973)(2005CB623903)
中文摘要
目的评价共聚物胶束对9-硝基喜树碱(9-NC)内酯环稳定性的影响。方法采用HPLC法测定,以甲醇-PBS(70:30,pH6.5)为流动相,检测波长370 nm,流速1 ml.min-1。结果内酯和羧酸盐形式的9-NC能完全分离;在PBS(pH7.4)中培养160 min后,载药胶束中具有抗肿瘤活性的9-NC内酯比例占80%,而无胶束包覆的原料药中内酯比例仅15%。结论共聚物胶束能有效提高9-NC内酯环结构的稳定性。
英文摘要
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