2-邻苯二甲酰亚胺-2-去氧-β-D-半乳吡喃糖乙硫苷供体制备工艺的优化
Optimization on preparation of ethyl 2-deoxy-2-phthalimido-1-thio-β-D-galactopyranoside donor
作者：罗盛;黄蕾;杨劲松;
Author：
收稿日期： 年卷（期）页码：2020,35(04):-355-358
期刊名称：华西药学杂志
Journal Name：WEST CHINA JOURNAL OF PHARMACEUTICAL SCIENCES
关键字：硫酸软骨素;寡糖合成;2-氨基-2-去氧-D-半乳糖盐酸盐;邻苯二甲酰亚胺基;叔丁基二甲基硅基;乙硫苷供体;合成;制备工艺优化
Key words：
基金项目：国家自然科学基金资助项目(批准号:21772132)
中文摘要
目的优化2-邻苯二甲酰亚胺-2-去氧-β-D-半乳吡喃糖乙硫苷供体的制备工艺。方法以2-氨基-2-去氧-D-半乳糖盐酸盐为原料,采用氨基保护、苯亚甲基化和硅基化等7步化学反应,利用1HNMR、13CNMR及LC-MS(ESI)验证化合物的结构。结果以总收率为25.4%制备了化合物Ⅰ。结论所用方法比报道的反应步骤减少两步,提高了制备效率。
英文摘要
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