无细胞再生性牙髓治疗的现状及展望
Progress and perspectives on cell-free regenerative endodontic therapy
作者:周建, 苏盈盈, 王松灵
Author:Zhou Jian, Su Yingying, Wang Song-ling
收稿日期:2021-06-16 年卷(期)页码:2022,40(1):1-1-6
期刊名称:华西口腔医学杂志
Journal Name:West China Journal of Stomatology
关键字:无细胞再生性牙髓治疗,细胞归巢,干细胞,组织工程,
Key words:cell-free regenerative endodontic therapy,cell homing,stem cell,tissue engineering,
基金项目:中国医学科学院牙齿发育与再生创新单元(2019-12M-5-031);北京市医院管理局使命计划(SML20151401);北京市教委人才培养项目(119207020201);“北京学者”计划项目(PXM-2020_014226_000005,PXM2019_014226_000039,PXM2019_014-226_000011,PXM2018_014226_000021,PXM2017_014226_0000-23,PXM2018_193312_000006_0028S643_FCG,PXM2016_01422-6_000034);国家自然科学基金委员会重大研究计划(91649124);国家自然科学基金委员会面上项目(82170951);北京市自然科学基金面上项目(7222079)
中文摘要
患牙髓/根尖周病变的牙齿经过根管治疗后可得以保留,但是失去牙髓的患牙易发生再次感染和牙纵裂等并发症。随着组织工程和生物材料的发展,以生物学为基础的牙髓牙本质复合体再生或修复治疗成为可能。无细胞再生性牙髓治疗已经成为儿童和青少年年轻恒牙牙髓坏死的有效治疗方法,对成熟恒牙的治疗也在探索中。
英文摘要
Although teeth with pulpitis/apical periodontitis are saved after successful endodontic therapy, they are devitalized and susceptible to reinfections and fractures. The development of biology-based approaches for dental pulp regeneration or repair is possible today because of recent advances in tissue engineering and biomaterials. Cell-free regenerative endodontic therapy offers a promising strategy for the treatment of necrotic immature permanent teeth in children and adolescents. However, studies are underway to determine whether this procedure can be applied to mature teeth.
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