Objective To observe changes in tongue and hyoid position, and pharyngeal airway in patients with skeletal class Ⅲ malocclusion after the combined orthodontic and orthognathic treatment. Methods Twenty patients were involved in this study. Cone beam CT（CBCT） was performed on patients one week before and six months after treatment. Raw data were reconstructed into three-dimensional model. To set up a three-dimensional reference frame, which was based by point “S”, the sagittal and transversal measurements, cross sectional areas, partial and total volumes were computed. The three-dimensional position changes of chin, hyoid bone and tongue were measured in order to analyze the amount of mandibular setback relationship with the changes of pharyngeal airway, hyoid bone and tongue positions. Results After treatment, the pharyngeal airway was constricted significantly. The hyoid significantly moved inferoposteriorly by 5.72 mm（backward） and 2.76 mm（downward） and the tongue moved posteriorly by 4.04 mm after surgery（P
