新型纳米抗菌无机填料的合成及其抗菌性能的初步研究
Study on synthesis on a novel nano-antibacterial inorganic filler and its antibacterial property
作者：吴峻岭1 金婵媛1 聂晓萌1 周凯运2 周传建2
Author：Wu Junling1, Jin Chanyuan1, Nie Xiaomeng1, Zhou Kaiyun2, Zhou Chuanjian2
收稿日期：2011-12-12 年卷（期）页码：2012,30(5):526-526-529
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：复合树脂, 抗菌性, 无机填料, 季铵盐,
Key words：composite resin, antibacterial property, inorganic filler, quaternary ammonium salt,
基金项目：
山东省优秀中青年科学家科研奖励基金资助项目（BS2010YY020）；山东大学自主创新基金资助自由探索项目（2010TS079）
中文摘要
目的合成新型的纳米抗菌无机填料，为赋予牙科复合树脂抗菌性能提供新的思路。方法通过有机合成的方法，首先合成了季铵盐：N,N,N-三甲基-3-（三甲氧基硅基）丙基-1-碘化铵，然后再将其枝接到纳米二氧化硅颗粒表面，得到新型纳米抗菌无机填料季铵盐修饰纳米二氧化硅，并对合成产物结构进行表征。然后以变异链球菌为对象，研究季铵盐修饰纳米二氧化硅的抗菌性能。结果红外光谱分析表明，季铵盐成功地枝接到了纳米二氧化硅颗粒表面。与对照组相比，新型纳米抗菌无机填料对变异链球菌具有较强的杀菌作用（P
英文摘要
Objective To synthesize a novel nano-antibacterial inorganic filler and provide a new way to give dental composite resin antibacterial property. Methods Quaternary ammonium iodide N,N,N -trimethyl -3 -（trimethoxysilyl） propan-1-aminium iodide were organically synthesized firstly and then the N,N,N-trimethyl-3-（trimethoxysilyl） propan-1-aminium iodide was grafted to the nano-silica particle to synthesize the antibacterial inorganic fillers nano-silica particle grafted with quaternary ammonium salt. All the products were analyzed and identified by infrared spectrum analysis. Then Streptococcus mutans were chosen as experimental object to analysis the antibacterial property of nanoantibacterial inorganic filler. Results Quaternary ammonium salt was grafted to the surface of nano-silica particles successfully by infrared spectrum analysis. Compared with the control group, the nano-silica particle grafted with quaternary ammonium salt had a strong bactericidal effect on Streptococcus mutans（P
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