一氧化氮对舌下神经核兴奋作用的影响
Nitric oxide acts as an excitatory neurotransmitter at hypoglossal motor nucleus
作者：吴海莺 Liu Hattie Horner Richard L 刘流
Author：Wu Haiying1, Liu Hattie2,Horner Richard L2, Liu Liu3
收稿日期：2012-06-25 年卷（期）页码：2012,30(3):317-317-320
期刊名称：华西口腔医学杂志
Journal Name：West China Journal of Stomatology
关键字：一氧化氮,舌下神经核,神经递质,颏舌肌,阻塞性睡眠呼吸暂停综合征,
Key words：nitric oxide,hypoglossal motor nucleus,neurotransmitter,genioglossus,obstructive sleep apneahypopnea syndrome,
基金项目：
中文摘要
目的观察一氧化氮（NO）及其清除剂对舌下神经运动核（HMN）活动的影响并初步探讨其机制。方法麻醉雄性成年Wistar大鼠，微透析探针先透析人工脑脊液（ACSF）到HMN作为对照，然后再分别持续给予二乙胺一氧化氮水合钠盐（DEA，NO供体）和2-（4-羧基苯基）-4,4,5,5,-四甲基-1,3-二氧咪唑啉钾盐（carboxy-PTIO，NO清除剂）到HMN，观测大鼠颏舌肌（GG）、膈肌电活动及血压和呼吸频率的变化。结果给予DEA后，大鼠的呼吸相关GG活动明
显增加，而给予carboxy-PTIO后则明显降低，与ACSF时的值相比差异均有统计学意义（P0.05）。结论NO作为一种神经递质对HMN产生兴奋，从而对维持生理状态下上气道的开放起重要作用。
英文摘要
Objective The study is to observe the effect of nitric oxide（NO） donor and scavenger to the hypoglossal motor nucleus（HMN） activity and explore the underlying mechanism. Methods Male adult anesthetized Wistar rats were anesthetized. The activity of genioglossus（GG）, diaphragma, blood pressure（BP） and respiratory rate（RR）were recorded when constant microdialysis perfusion of artificial cerebrospinal fluid（ACSF） to HMN as control, followed with diethylamine NONOate sodium salt hydrate（DEA）, a NO donor, and 2-（4-carboxyphenyl）-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide potassium salt（carboxy-PTIO）, a NO scavenger. Results Compared with ACSF, application of DEA and carboxy-PTIO at HMN increased and decreased the GG activity respectively and significantly（P
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