Objective To evaluate the effects of angle Class Ⅱ division 2 malocclusion treated with Herbst appliance in young adults. Methods Cast splint Herbst appliance and multi-bracket appliance were used to treat 12 patients with Class Ⅱ division 2 malocclusion aged from 16 to 25 years old. The lateral cephalograms were measured with Winceph 8.0 software and statistical analysis was carried out by SPSS 13.0 software. Results The changes in SNA, Co- Go, Go-Po after treatment had no statistical significance(P>0.05). The SNB increased and ANB decreased after treatment. Upper and lower incisors labially inclined and inter-incisor angle increased. Upper posterior teeth had distal movement, lower posterior teeth had mesial movement and extrusion. Mandibular plane angle and occlusal plane angle had clockwise rotation. The overbite decreased significantly, and the molar relationship changed from Class Ⅱ to Class Ⅰ in all patients. Conclusion Herbst appliance combined with multi-bracket appliance can be used effectively for correcting Class Ⅱ division 2 malocclusion in young adults.