期刊导航

论文摘要

人类基因组计划和人类基因组单体型图计划:口腔医学的机遇、挑战与对策思考

Human genomic project and human genomic haplotype map project:Opportunitiy, challenge and strategy in stomatology

作者:吴瑞卿 曾昕 王智

Author:WU Rui-qing, ZENG Xin, WANG Zhi

收稿日期:2010-08-25          年卷(期)页码:2010,28(04):457-457-460

期刊名称:华西口腔医学杂志

Journal Name:West China Journal of Stomatology

关键字:人类基因组计划,人类基因组单体型图计划,口腔,遗传易感性,

Key words:human genomic project,human genomic haplotype map project,stomatology,genetic susceptibility,

基金项目:

国家自然科学基金资助项目(30801294和30725041)

中文摘要

人类基因组计划和人类基因组单体型图计划的实施与逐步完成,构建起一张精度更高信息更完整的多人种遗传多态图谱,有望破译人类遗传密码,实现疾病的分子诊断与个体化治疗。本文简要在回顾人类基因组计划和人类基因组单体型图计划的建立过程、目标和已获得成果的基础上,提出口腔医学领域通过人才培养模式的改进,多学科交叉联合,加强国家口腔医学研究基地的建设,启动口腔医学领域国家重大基础研究计划4个方面的应对策略,以迎接挑战。

英文摘要

The human genomic project and the international HapMap project were designed to create a genomewide database of patterns of human genetic variation, with the expectation that these patterns would be useful for genetic association studies of common diseases, thus lead to molecular diagnosis and personnel therapy. The article briefly reviewed the creation, target and achievement of those two projects. Furthermore, the authors have given four suggestions in facing to the opportunities and challenges brought by the two projects, including cultivation improvement of elites, cross binding of multi-subjects, strengthening construction of research base and initiation of natural key scientific project.

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